Ornithine decarboxylase: a promising and exploratory candidate target for natural products in cancer chemoprevention.
نویسنده
چکیده
Ornithine decarboxylase (ODC), the first enzyme in the polyamine biosynthesis, plays an important role in tumor progression, cell proliferation and differentiation. In recent years, ODC has been the subject of intense study among researchers, as a target for anti-cancer therapy and specific inhibitory agents, have the potential to suppress carcinogenesis and find applications in clinical therapy. In particular, it is suggested that ODC is a promising candidate target for natural products in cancer chemoprevention. Future exploration of ornithine decarboxylase inhibitors present in nature may offer great hope for finding new cancer chemopreventive agents.
منابع مشابه
Cancer chemoprevention locks onto a new polyamine metabolic target.
Ornithine decarboxylase has a relatively long history as a target for cancer chemoprevention and chemotherapy. Plym Forshell et al. report new evidence (beginning on p. 140 in this issue of the journal) indicating that spermidine synthase, a fellow enzyme of ornithine decarboxylase in polyamine metabolism, is transactivated in part by the MYC gene and is a potential target for chemoprevention o...
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عنوان ژورنال:
- Asian Pacific journal of cancer prevention : APJCP
دوره 13 5 شماره
صفحات -
تاریخ انتشار 2012